Leukocyte adhesions deficiency (LAD) syndromes are a group of infrequent disorders which affects the immune system. LAD syndromes are categorized by flaws which affects the way white blood cells (leukocytes) react and travel to the wound or infection site. There are three different kinds of leukocyte adhesion syndrome which have been recognized. The precise severity and symptoms of LAD syndromes differ from person to person. All individuals affected build up an augmented vulnerability to developing recurring fungal and bacterial infections.
Standard Therapies for Leukocyte Adhesion Deficiency (LAD)
The LAD syndrome treatment is directed to the precise symptoms that are obvious in every individual. The major treatment aspect is antibiotic therapy for the treatment of the characteristic, repeated, infections related to the LAD syndrome disorders. Quick antibiotic therapy is vital throughout acute episodes of infections. People with mild or moderate kinds of LAD I or LAD II typically react to conservative and quick therapy for acute episodes. The preventive antibiotic therapy might be essential for some people having more severe LAD I forms.
Genetic counseling might be of advantage for individuals who are affected and their families.
Investigational Therapies for Leukocyte Adhesion Deficiency (LAD)
The one and only curative therapy for people having LAD syndromes is a transplant of the bone marrow. A bone marrow transplant might also be recognized as a stem cell transplant. The hematopoietic stem cells are distinct cells which are found in the bone marrow that produces diverse kinds of blood cells (e.g., white blood cells, red blood cells, platelets). In allogeneic transplantation of stem cell, stem cells are donated from some other person, typically from a family member who is closely matched. Transplants of the stem cell have the potential to correct the genetic, inherent white blood cells defect in individuals having LAD syndromes.
However, as the stem cell transplants can produce severe, even dangerous problems, they are typically reserved for persons having severe problems or people who have no other possible treatment options. The early outcomes of bone marrow transplants for people with the severe LAD I have been very positive.