Loss of Y chromosome linked to Alzheimer’s disease – Study

Loss-of-Y-chromosome-linked-to-Alzheimer’s-diseaseResearchers, Professor Lars Forsberg and Jan Dumanski of the ‘Department of Immunology, Genetics and Pathology at Uppsala University in Sweden’, use a new tool study genetic variations that are assemble with the progression of age. They investigated that those with an existing diagnosis of Alzheimer’s disease have a greater degree of loss of Y chromosome. Researches inaugurated cases of LOY chromosomes in more than 3200 men with the average age of 73.
Around 17 percent men are diagnosed with LOY

“Having LOY is not 100 percent predictive that you will have either cancer or Alzheimer’s,” cautioned Forsberg.

According to the study some of the men having LOY live with no symptoms well into their 90’s.


LOY in the blood cells become a new biomarker for risk of the diseases and possibly interpretation can make a difference in treating and detecting the complications, in the future.

According to Chris Lau, professor in the department of medicine at the University of California, San Francisco, and the study cast off little light on why Alzheimer’s risk may be exhilarated in these men.

“Although informative, the study is preliminary in nature and only highlights the fact that the Y chromosome could serve important functions beyond male sex determination and sperm production,” said Lau, who was not involved in the study.

What is exactly the key issue on Y chromosomes that develop the risk of Alzheimer’s disease?

“It depends on what is lost to determine what is important for Alzheimer’s disease. Without such information, the loss of Y is just an observation,” Lau said.


The article is designed on the issue of loss of Y chromosome that can linked to Alzheimer’s disease the researches are taken from a news paper of Thailand The Nation.


Note: The above material is edited for content and length.

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